Although there is no "Hide behind cover" button, it is possible to use Crouch behind walls, vehicles or other obstacles.
The Crouch can also increase your accuracy with a rapid-fire weapon.
Using Human Shields is a fast way to disarm enemies, allows them to be instantly killed, and provides protection against attacks from other enemies.
Sprint as fast as possible away from grenades when they show on your HUD.
Shooting the driver through the window is faster than destroying the vehicle.
Use short, controlled bursts against enemies and try not to spray unless at close range; at all other distances, aim high. If your sights settle on their chest, it is generally more than enough to pull your aim upwards and score a headshot.
Explosives are great against shielded and slow-moving enemies.
Completing Pushbacks earns $500. While a neighborhood is under attack, no City Income is earned for that neighborhood.
Professor Genki can sometimes be seen wandering around Steelport. If you want to bring the fight to him, pack all the weapons and ammo you can spare. Be warned, he is a tough guy but will surrender substantial rewards if you do kill him.
Health in Saints Row: The Third and Saints Row IV during real world missions recovers overtime.
The Alien Rifle and Xmas BB Gun with their Ultimate Upgrades are helpful in restoring health, and the Alien Rifle's Vampiric Ammo upgrade becomes much more useful outside the Simulation as there are no health pick ups in the real world, and there is no upgrades for faster health regen in Saints Row IV.