- Not to be confused with Mayhem.
- "The [objective] of Mayhem is to cause as much monetary destruction as possible in a set time limit. We thought that was fun, and then we decided to go ahead and add a tank."
- — Drew Holmes
- Level 1 - $125,000
- Level 2 - $250,000
- Level 3 - $500,000
After completing all 6 levels, Guardsmen become available as a Homies style.
- In the downtown hard instance of Tank Mayhem, a STAG Crusader will always appear almost out of view, even before they arrive in Steelport.
- Female Voice 1 can sometimes be heard breaking the fourth wall in this activity by saying: "If you want to live, you shouldn't be a target next time"