After hearing that The Protagonist had awoken, he got himself stabbed to be taken into the infirmary. After an exchange of words, he managed to convince The Protagonist to escape with him. They broke out of the infirmary after killing a doctor, killed all of the guards who stood in their way, and then broke out of the prison and escaped on a boat.
After their escape, The Protagonist chose to recruit Carlos as a lieutenant. Carlos willingly accepts this, but asks a favor, he wants him to steal a car off a guy called Ramon who owed him money.
After stealing the car, Carlos was assigned to deal with the Brotherhood led by Maero. However, Carlos wasn't as skilled at retrieving information like Shaundi and Pierce, but The Protagonist, who had taken a liking to Carlos, told him that he "will make him a banger, even if it kills him."
But after they poisoned Maero's tattoo ink with radioactive waste, which resulted in Maero's face being badly burned, Carlos was kidnapped by the Brotherhood (on Maero's girlfriend Jessica's order), chained to a truck's trailer hitch, and dragged through the docks. The Protagonist kills the Brotherhood members driving the truck dragging Carlos, but couldn't arrive in time, as Carlos was badly injured being dragged at high speed. Seeing as there was no way to release him from the chain, Carlos nods at The Protagonist to put him out of his misery who does so by shooting him in the head.
Carlos' voice actor, Joe Camareno, also plays the voices of random peds in both the Saints Row games such as Los Carnales and Saints members.
The Brotherhood missions are the only gang missions that Carlos is seen in (barring the prologue missions associated with the 3rd Street Saints). This is due to the fact that the player may participate in different gang missions after Carlos' death.
In an in-game newspaper for the Red Asphalt mission, it mentions a deceased person named Hector; this is a reference to Hector, the Trojan Prince of the Greek myth of the Iliad, where Hector's corpse is dragged around behind a chariot for days.
Carlos usually puts his head down in shame, due to the fact that he has poor self esteem.
It would seem as though The Protagonist saw Carlos as a little brother figure.
Jessica mentions that Carlos reminds her of her old house cleaner, due to him being Hispanic.
There is an inaccessible store in-game named "Carlos Cleaning".
If the generic Saints members are Taunted by The Protagonist, they may respond by blaming him for Carlos' death.
Carlos is seen in the manual punching a Samedi shirtless and not wearing his beanie.
There is a misconception[reference?] that The Protagonist betrays Carlos during the mission Red Asphalt, whereas in reality he is peforming a Mercy Killing.
In Saints Row: The Third, Carlos has an article written about him in the hidden content magazine "Boy Toy".[screenshot?] While the article summary is difficult to read, the best guess is that he has some sort of influence on fashion.
It is said during an interview with one of the developers of the Saints Row series is that, one of the reasons why they give the player choices in SR3 was because they regretted having The Protagonist perform a mercy killing on Carlos, instead of allowing him to live.
Out of all of the Saints Row 2 lieutenants, Carlos appears in the least amount of missions, due to dying so early in the Brotherhood storyline.