After hearing that The Protagonist has awoken, he gets himself stabbed on purpose and taken into the infirmary. After an exchange of words, he convinces The Protagonist to escape with him. They break out of the infirmary after killing the doctor and the guards who stood in their way, and then escape the prison island on a boat.
After their escape, The Protagonist chooses to recruit Carlos as a lieutenant. Carlos willingly accepts this, but asks a favor: he wants The Protagonist to steal a Reaper hearse off a guy called Ramon who owed him money.
After stealing the car, Carlos is assigned to deal with the Brotherhood led by Maero. Carlos isn't as skilled at retrieving information as Shaundi or Pierce, but The Protagonist, who has taken a liking to Carlos, assures him that they "will make him a banger, even if it kills me."
After poisoning Maero's tattoo ink with radioactive waste, Carlos is kidnapped by the Brotherhood on the orders of Jessica, chained to a truck's trailer hitch, and dragged through the docks. The Protagonist kills the Brotherhood members driving the truck dragging Carlos, but couldn't arrive in time, as Carlos was badly injured being dragged at high speed. Seeing as there is no way to release him from the chain, Carlos nods at The Protagonist to put him out of his misery, and they do so by shooting him in the head.
The in-game newspaper for the "Red Asphalt" mission, mentions a deceased person named Hector; this is a reference to Hector, the Trojan Prince of the Greek myth of the Iliad, where Hector's corpse is dragged around behind a chariot for days.
Carlos usually puts his head down in shame, due to the fact that he has poor self esteem.
There is an inaccessible store in-game named "Carlos Cleaning".[where?]
If the generic Saints members are taunted by The Protagonist, they may respond by blaming them for Carlos' death.
In the manual, Carlos is depicted punching a Samedi shirtless and not wearing his skullcap.
One interpretation of the mission "Red Asphalt" states that The Protagonist betrays Carlos during the ending cutscene, whereas in reality they are performing a Mercy killing.
In Saints Row: The Third, Carlos has an article written about him in the hidden content magazine "Boy Toy". While the article summary is difficult to read, the best guess is that he has some sort of influence on fashion.
It is said during an interview with one of the developers of the Saints Row series that one of the reasons choices were added to Saints Row: The Third was because they regretted having The Protagonist perform a mercy killing on Carlos, instead of allowing him to live.
Out of all of the Saints Row 2 lieutenants, Carlos appears in the least amount of missions, due to dying so early in The Brotherhood storyline.
When Pierce is a recruited as a homie in Saints Row 2, he sometimes says "pretty messed up what happened to Carlos", making him the only lieutenant in the game to acknowledge Carlos' death.
Carlos Ramón Mendoza is the name of a professional baseball player. Ramon is the name of the person who owes Carlos money. Additionally, Carlos somewhat resembles musician Daddy Yankee, whose name is also Ramon.
↑Story: The following text has been transcribed verbatim from the game files. It can be read in-game upon completion of the mission by selecting the mission at a Newspaper Clipboard.
A member of the Third Street Saints was found dead today, the victim of a grisly gangland assassination. In a bloody recreation of the fate of Hector, Carlos Mendoza's body was dragged face down across Stilwater, until mercifully being shot in the head. While no arrests have been made in the killing, the police suspect the Brotherhood as the ones responsible for the vicious attack.