The Carnales are headed by the Lopez Brothers, taking over after the death of their father with older brother Hector as the leader and younger brother Angelo as his number 2. Victor Rodriguez is their enforcer, a man of imposing physical strength and endurance. Luz Avalos is Angelo's girlfriend, though there is a suggestion of an affair between her and the gang's liaison with Colombian drug cartels, Manuel Orejuela creating a tense situation between him and Angelo.
Los Carnales were the first organised gang of Stilwater, founded by Alejandro Lopez, who is the father of Hector and Angelo. With Colombian cartel backing, Los Carnales spread throughout Stilwater in a matter of months. 
Their dominance was ended when Benjamin King grew tired of the violence in Sunnyvale Gardens  and organised the local youths into a new gang, the Vice Kings, which drove Los Carnales out of "the Gardens" in a matter of days.  After months of warfare, Los Carnales were greatly reduced in power and the Vice Kings had become the new force in Stilwater. However, once Benjamin King began focusing on building legitimate power, the Carnales expanded once again; by the time The Protagonist joins the 3rd Street Saints, Los Carnales once again have a significant presence in the city, dominating most of the Southern Island. Their deep running connections with Colombians drug czars, keeping them supplied with drugs and all the weapons needed for fighting wars, and the Lopez Brothers' psychotic reputation made the Saints leery of attacking them directly. 
The Carnales have a stronghold in territory of the 3rd Street Saints, an abandoned liquor store located in Athos Bay.  After the Saints' takeover of that stronghold, the gang was one of four that engaged in a violent turf battle for control of the Saints Row area, culminating in a victory by the Saints and the retaking of their home territory.  After this, the Saints began hitting the Carnales even harder, crossing out tags, hitting drug labs  and hijacking a shipment of drugs.  This causes the Saints to appear on the Carnales' radar, with Manuel becoming concerned that the Lopez brothers can not secure drug shipments.[reference?] In retaliation, Los Carnales launches its own pre-emptive attack against the Saints territory.  The attack is pushed back, and the Saints retaliate in turn even harder, and becomes that much more aggressive in the ongoing war between these two organizations. Using the truck that was carrying the drugs they hijacked, they infiltrate a Carnales drug lab and engage the Carnales in a fierce gun battle, killing all of the Carnales on site.
Hector decides to continue as planned with meeting the Colombians at a major shipment, personally with an entourage of rocket-launcher toting bodyguards. Despite the number of elite guards, Hector and his guards are assassinated by a sniper.  Although the sniper is The Protagonist, in the confusion it is initially thought by the Carnales that one of the Colombians had fired the shot. Victor, either present at the docks or arriving after the fact, reports to Angelo that his brother is dead. This sends him flying into a rage. 3rd Street Boss, Julius, sees an opportunity to get into the lucrative drug trade within Stilwater, sending representatives to meet with Manuel at a Tee'N'Ay. Instead, they are ambushed by Carnales shooters lead by Victor. 
Barely escaping, the representatives make their way back to Mission Beach. Not too long after that, Victor hits the Row again. This time leading a direct attack on the church. After an extremely fierce gun battle in the middle of the streets of Mission Beach, Victor assaults 3rd Street himself in his customized Bulldog SUV. After smashing the SUV with K6s, AR40s and other automatic arms, it is heavily damaged and eventually explodes. This, does not stop Victor, who comes out of the flaming wreckage and attacks the Saints whilst on fire himself, much to the surprise of the Saints. Despite this, Victor is eventually killed. 
A distraught Angelo vowed to take revenge for his brother and friend, straining his relationship further with Luz. Meanwhile for the Saints, the Colombians issue an ultimatum: they will work exclusively with the Saints if they can return the confiscated cocaine to them from a police lock-up. To do this, the Saints formulate a plan to use a car bomb to blow a hole in the wall of the police evidence locker and steal back the Colombians cocaine. After a tense drive to the station, the Saints detonate the bomb, steal the cocaine and make a frantic run back to a garage with the police on their tail. 
Manuel meets with Julius at a strip club to formulate a business deal. The meeting is interrupted by Angelo who opens fire with an automatic assault rifle, meaning to avenge the death of his brother by killing all involved. He is unsuccessful and quickly retreats. Manuel then offers the Saints his home address.  Assaulting the Lopez Mansion, the Saint's take it over, but Angelo escapes after a wild chase through the city. 
With the Carnales leadership decimated, and the drug and weapons production capabilities all but destroyed, Angelo now attempts to leave the city to rebuild his gang at a later date. The Saints become aware of this, and strike at the airport where Angelo's private jet is preparing to take off. Despite tight security, a pair of Saints manage to destroy the Jet, and everyone on-board, on the runway. Luz, at the airport to meet with Angelo, arrives at the very end of the fight and is met by Angelo's killers. Despite some threats of violence, they let Luz go unharmed.  She is later shown at a bar with Manuel.
- Most Los Carnales vehicle radios are set to 89.0 Generation X, and some of them are set to 102.4 Klassic FM.[which?]
- Los Carnales is Spanish for "The Brothers".
- They are incorrectly called "the Los Carnales" by Troy, an anonymous Saints gang member, and Dex who tries to correct the former two until he says it incorrectly.
- Los Carnales are the only gang to appear in the attract mode demo that plays during the Saints Row title screen.
- Some Los Carnales tags are still present during Saints Row 2 in the southern districts of Stilwater once controlled by them, such as inside the Drug Factory.
- ↑ 1.0 1.1 1.2 1.3 Mission: Crack Down
- ↑ 2.0 2.1 2.2 2.3 2.4 Church tour
- ↑ Stronghold: Abandoned Storefront
- ↑ Mission: Reclamation
- ↑ Activity: Tagging
- ↑ 6.0 6.1 6.2 Mission: The Missing Shipment
- ↑ 7.0 7.1 7.2 Mission: Homeland Security
- ↑ Mission: Trojan Horse
- ↑ Mission: McManus Says Hello
- ↑ Mission: Meeting Orejuela
- ↑ Mission: Strength in Numbers
- ↑ Mission: Possession with Intent
- ↑ Cutscene: Courting the Colombians
- ↑ Mission: House Call
- ↑ Mission: What Goes Up...
- ↑ Cutscene: Battlefield Promotion